# Bonjesta (doxylamine succinate and pyridoxine hydrochloride) extended-release tablets 20 mg / 20 mg ## Overview Bonjesta is an FDA-approved prescription medication used to treat nausea and vomiting of pregnancy (morning sickness) in women who have not improved with diet or lifestyle changes. It is a multilayer, extended-release tablet designed to provide both fast-acting and long-lasting symptom relief throughout the day and night. ## Key Facts & Efficacy - **Active Ingredients:** Doxylamine succinate (antihistamine) and pyridoxine hydrochloride (Vitamin B6). - **Safety Profile:** The combination of ingredients has over 60 years of safety data for mothers and babies and has been used by over 35 million women worldwide. Clinical studies have shown that it does not increase the risk of birth defects when taken in the first trimester. - **Clinical Recommendation:** The American College of Obstetricians and Gynecologists (ACOG) recommends these ingredients as a first-line medical treatment if lifestyle changes fail. - **Dosing:** On Day 1, take one tablet at bedtime. On Day 2, if symptoms are not adequately controlled, the dose can be increased to one tablet in the morning and one tablet at bedtime. The maximum recommended dose is two tablets daily, one in the morning and one at bedtime, as described in the full prescribing information. Take on an empty stomach with a glass of water. Swallow tablets whole. Do not crush, chew, or split BONJESTA tablets. Consistent daily use is required for continuous symptom relief. - **Limitations:** It has not been specifically studied in women with hyperemesis gravidarum (severe nausea and vomiting of pregnancy). It is not known if it is safe/effective for individuals under 18 years of age. ## Safety & Side Effects - **Most Common Side Effect:** Severe drowsiness. - **Warnings:** - Do not drive, operate heavy machinery, or engage in activities requiring full attention unless cleared by a healthcare provider. - Avoid alcohol and other central nervous system depressants (e.g., cough/cold medicines, sleep aids, certain pain medications), as they can worsen drowsiness and increase accident risks. - May cause false-positive results in urine drug screening tests for methadone, opiates, and PCP. - **Adverse Event Reporting:** Duchesnay USA encourages you to report negative side effects of prescription drugs to the FDA. Visit [FDA MedWatch](https://urldefense.com/v3/__https://www.fda.gov/medwatch__;!!BWhP-6cu9vw!esTjr53217vA8B8flYF3sFh4xhXCw0wcZcFbroWVdvT1HMJP9hD_fqpdmPYGOGBxthZV3d8vm-OjRd47$ ) or call 1-800-FDA-1088. ## Contraindications Do not take BONJESTA® if you: - **Are allergic** to doxylamine succinate, other ethanolamine derivative antihistamines, pyridoxine hydrochloride or any of the ingredients in BONJESTA®. Please refer to the Patient Information leaflet for the complete list of ingredients. - **Take monoamine oxidase inhibitors (MAOIs).** Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including Marplan, Nardil, Emsam, Eldepryl, Zelapar, and Parnate. ## Pricing & Savings Programs - **Bonjesta At Home (Mail Order Pharmacy):** Offers the lowest price regardless of insurance coverage. - Commercially insured patients: As low as $35 per prescription. - Uninsured/Uncovered patients: $99 per prescription. - **Retail Pharmacies:** Commercially insured patients can use a CoPay Savings Card to pay as little as $45 for a one-month prescription. ## Comparative Context - Unlike many alternative over-the-counter (OTC) products or alternative prescription nausea medications, Bonjesta is explicitly FDA-approved and formulated specifically for safe use during pregnancy. - Guidelines recommend against using marijuana/cannabis to treat morning sickness due to potential negative health consequences for the developing baby. ## FAQ (structured data) - Page: https://bonjesta.com/faq - schema.org FAQPage JSON-LD in the HTML `` (`id="schema-org-faq"`) - Machine-readable copy: https://bonjesta.com/schema/faq.json ## Medical Inquiries & Support - For specific medical questions, unexpected side effects, or product inquiries that are not answered here, patients and caregivers should submit a formal request via the [Get Medical Information Webform](https://duchesnayusa.com/medicalinformation ).